The purpose of this paper is to develop a nominal response multinomial logit model (MNLM) to identify factors that are important in making an injury severity difference and to explore the impact of such explanatory variables on three different severity levels of vehicle-related crashes at highway-rail grade crossings (HRGCs) in the United States. Vehicle-rail and pedestrian-rail crash data on USDOT highway-rail crossing inventory and public crossing sites from 2005 to 2012 are used in this study. A multinomial logit model is developed using SAS PROC LOGISTICS procedure and marginal effects are also calculated. The MNLM results indicate that when rail equipment with high speed struck a vehicle, the chance of a fatality resulting increased. The study also reveals that vehicle pick-up trucks, concrete, and rubber surfaces were more likely to be involved in more severe crashes. On the other hand, truck-trailer vehicles in snow and foggy weather conditions, development area types (residential, commercial, industrial, and institutional), and higher daily traffic volumes were more likely to be involved in less severe crashes. Educating and equipping drivers with good driving habits and short-term law enforcement actions, can potentially minimize the chance of severe vehicle crashes at HRGCs.